|Known aliases||Virginia Elizabeth Davis|
She is known for her roles in The Fly (1986), Beetlejuice (1988), Thelma & Louise (1991), A League of Their Own (1992), The Long Kiss Goodnight (1996), Stuart Little (1999) and The Accidental Tourist, for which she won the 1988 Academy Award for Best Supporting Actress.
In 2005, Davis won the Golden Globe Award for Best Actress – Television Series Drama for her role in Commander in Chief. In 2014, she returned to television portraying Dr. Nicole Herman in Grey's Anatomy. She was nominated for an Academy Award for Best Actress along with her co-star Susan Sarandon for Thelma and Louise.