He was a CEO of Weyland Corporation and he funded the expedition to find The Engineers, the creators of humankind. He also manufactures the first advanced android prototype model of its kind. He affectionately calls him David. He has a daughter called Meredith Vickers.
In 2091, after Elizabeth Shaw and Charlie Holloway interpreted a star map appearing across several unconnected ancient cultures as an invitation by humanity's creators, Peter Weyland funded the creation of the scientific vessel USCSS Prometheus to follow the map to LV-223. Unbeknownst to any of the Prometheus crew other than David, his daughter Vickers, who joins him, his bodyguards and doctor. However, Weyland was secretly aboard the Prometheus in hypersleep throughout the two-year journey and subsequent mission, as Weyland was by 2091 old and expected to die soon and hoped that the Engineers would be able to extend his lifespan.
He was killed by an Engineer in LV-223, when he was awakened.